胃癌组织中胃蛋白酶原表达与患者预后的相关性研究

The study of pepsinogen C expression and prognostic significance in gastric carcinoma

目的对胃癌组织中PGC表达进行检测,并分析与患者临床病理特征、生存状况的关联,探讨胃癌组织中PGC表达对胃癌患者预后的影响。方法随机抽取2001～2005年我院共70例经手术确诊胃癌患者,获取标本切片,采用免疫组织化学方法测定胃癌组织中PGC的表达率,同时随访。结果 70例随访患者中失访3例,10例肿瘤组织中PGC阳性表达(14.9%),进一步分析表明PGC表达与临床病理特征有显著关联。PGC低表达患者总体生存时间较短(P<0.05)。根据COX回归分析,TNM分期与PGC表达都是影响胃癌患者预后的独立因素(P<0.05)。结论PGC在胃癌组织中表达检测可作为胃癌患者预后的标志物,指导预后评估,从而使患者得到及时的后续治疗,改善预后。

Objective To research gastric carcinoma PGC expression and the prognosis, and reveal the correlation among PGC, clinicopathological features and GC prognosis. Methods Following up 70 cases of gastric cancer which were after surgical treatment in Tianjin general hospital from 2001 to 2005, and tissue samples of them were detected by immunohis- toehemistry method for expression of PGC. Results Three cases were missed in 70 cases, 10 cases of carcinoma expressed PGC （14.9%）. There was significant correlation between PGC expression and clinicopathological features. In the overall group of patients with GC, low expression of PGC predicted short overall survival periods （P 〈 0.05）. According to Cox＇ s model, multivariate analysis indicated expression of PGC and TNM staging were independent predictors for GC patients （P 〈 0.05）. Conclusion We can use PGC expression in tumor tissue for evaluating the prognosis of GC patients, so that the gastric cancer patients can receive timely follow-up treatment and improve prognosis.