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CD4^+CD25^+调节性T细胞与肝移植免疫耐受

CD4^+CD25^+ regulatory T cells and immune tolerance of liver transplantation
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摘要 CD4+CD25+调节性T细胞因其独特的免疫抑制功能而备受关注,在诱导和维持移植免疫耐受方面具有重要的作用。肝脏具有移植免疫特性,但肝移植术后如何避免排斥反应、诱导免疫耐受、提高存活率这一问题仍尚未解决。CD4+CD25+调节性T细胞在肝移植免疫耐受中具有重要的作用。本文即从CD4+CD25+调节性T细胞入手,对其在肝移植排斥反应与免疫耐受中的作用加以综述。 CD4^＋CD25^＋ regulatory T cells have attracted much attention because of their unique immunosuppressive, and play an important role in the induction and maintenance of transplant tolerance. Although its transplantation immunity characteristics,the problem of how to avoid liver transplantation rejection, induce immune tolerance and improve survival rate still unresolved. CD4^＋CD25^＋ regulatory T cells have an important role in the immune tolerance of liver transplantation. In this review,we discuss CD4^＋CD25^＋ regulatory T cells ,and its rejected reaction and immune tolerance in liver transplantation.
作者 刘亚飞 张捷 付必莽 李春满 董丽英
机构地区 昆明医学院第二附属医院肝胆外科
出处 《中国现代医生》 2012年第20期22-24,共3页 China Modern Doctor
基金 云南省卫生科技计划项目(2009NS063)
关键词 CD4+CD25+调节性T细胞 肝移植 免疫耐受 CD4^＋CD25^＋ regulatory T cells Liver transplantation Immune tolerance
分类号 R392.11 [医药卫生—免疫学]
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  • 1Sakaguchi S,Sakaguchi N,Asano M,et al.Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25).Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases[J].J Immunol,1995,155(3):1151.
  • 2Thornton AM,Shevach EM.CD4^+CD25^+immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production[J].Exp Med,1998,188(2):287.
  • 3Fontenot JD,Dooley JL,Farr AG,et al.Developmental regulation of Foxp3 expression during ontogeny[J].J Exp Med,2005,202(7):901.
  • 4Sakaguchi S,Setoguchi R,Yagi H,et al.Naturally arising Foxp3-expressing CD4^+CD25^+ regulatory T cells in self-tolerance and autoimmune disease[J].Curr Top Microbiol Immunol,2006,305:51.
  • 5Jaeckel E,von Boehmer H,Manns MP.Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes[J].Diabetes,2005,54(2):306.
  • 6Fontenot JD,Rasmussen JP,Gavin MA,et al.A function for interleukin 2 in Foxp3-expressing regulatory T cells[J].Nat Immunol,2005,6(11):1142.
  • 7Hartigan-O′Connor DJ,Poon C,Sinclair E,et al.Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain(CD127),allowing consistent identification and sorting of live cells[J].J Immunol Methods,2007,319(1-2):41.
  • 8Vang KB,Yang J,Mahmud SA,et al.IL-2,-7,and-15,but not thymic stromal lymphopoeitin,redundantly govern CD4^+Foxp^3+ regulatory T cell development[J].J Immunol,2008,181(5):3285.
  • 9Carreno BM,Bennett F,Chau TA,et al.CTLA-4(CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression[J].J Immunol,2000,165(3):1352.
  • 10McHugh RS,Whitters MJ,Piccirillo CA,et al.CD4^+CD25^+ immunoregulatory T cells:gene expression analysis reveals a functional role for the glucocorticod 2 induced TNF receptor[J].Immunity,2002,16(2):311.

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中国现代医生
2012年 第20期

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