血浆脂联素在急性心肌梗死患者合并心脏骤停中的意义

Clinical significance of plasma adiponectin concentrations in patients with ST-elevation myocardial infarction and cardiac arrest

目的观察急性心肌梗死患者合并心脏骤停入院时血浆脂联素的水平,并探讨脂联素在急性心肌梗死患者中的价值。方法选取首次诊断为急性ST抬高心肌梗死患者326例,根据随访1年结果,分为心脏骤停患者(心脏骤停组)21例,无心脏骤停患者(无心脏骤停组)305例,测定入院时血浆脂联素、CRP以及心肌肌钙蛋白-I(TN-I)等指标,对脂联素、CRP等生化指标与心脏骤停发生率的相关性进行分析。结果心脏骤停组血浆脂联素浓度明显低于无心脏骤停组,Logistic多元逐步分析显示心源性休克、低射血分数以及低血浆脂联素浓度与心脏骤停心肌梗死的发生独立相关。结论低血浆脂联素浓度可能是评估心肌梗死患者发生心脏骤停的独立危险因子。

Objective To observe the adiponectin levels on patients with acute myocardial infarction complicated with cardiac arrest, and to explore the value of adiponectin in patients with acute myocardial infarction. Methods According to a 1 years follow-up, 326 patients with the first diagnosis of acute ST elevation myocardial infarction were divided into cardiac arrest patients（cardiac arrest group） in 21 cases, without cardiac arrest patients（without cardiac arrest group） in 305 cases, while the baseline levels of adiponectin, NT-proBNP, CRP and TN-I were measured. Biochemical indexes and cardiac arrest occurred rate correlation was researched. Results Plasma adiponectin concentrations in cardiac arrest group were lower significantly than without cardiac arrest group. Multiple logistic regression analysis showed that cardiogenic shock,low ejection fraction, and low plasma adiponectin concentrations correlated independently to the cardiac arrest occurs. Conclusion Low plasma adiponectin concentrations may be an independent value to predict cardiac arrest occurring in patients with myocardial infarction.