硝酸异山梨酯直接静脉泵入治疗不稳定型心绞痛180例疗效观察

Observation of curative effects of direct intravenous pumping of Isoket in treatment of 180 patients with unstable angina

目的观察异舒吉直接静脉泵入治疗不稳定型心绞痛的临床疗效和安全性。方法选择180例确诊为不稳定型心绞痛患者给予异舒吉50 mL(50 mg)直接静脉泵入,初始剂量3 mL/h(50μg/min),逐渐加量至血压不低于90/70 mm Hg。对照组86例给予异舒吉10～20 mg加入250～500 mL液体稀释后50μg/min静脉滴入。观察两组用药前后心绞痛症状、心电图、血压、心率和不良反应。结果两组间有效率比较,差异无统计学意义(P>0.05)。不良反应治疗组为8.8%,对照组为26.7%,差异有统计学意义(P<0.05)。结论异舒吉直接静脉泵入治疗不稳定型心绞痛,操作方便,安全有效,值得临床推广。

Objective To observe the clinical effects and safety of direct intravenous pumping of Isoket in the treatment of unstable angina. Methods One hundred and eighty patients diagnosed with unstable angina were given direct intravenous pumping of 50 mL （50 mg） of Isoket, with the initial dose of 3 mL/h （50 μg/min）, and the dose was gradually increased until the blood pressure reached no less than 90/70 mm Hg. Eighty-six patients of the control group were given intravenous infusion of 10-20 mg of Isoket diluted in 250-500 mL of liquid at the speed of 50 ~g/roin. Symptoms of angina, electro- cardiogram, blood pressure, heart rate and adverse reactions of the two groups before and after medication were observed. Results Effective rates of the two groups were not statistically different （P 〉 0.05）. The adverse reaction rates were 8.8% in the treatment group and 26.7% in control group, with statistically significant difference （P 〈 0.05）. Conclusion Direct intravenous pumping of Isoket is easily operative, safe and effective in the treatment of unstable angina, thereby worthy of clinical promotion.