乙型脑炎脑组织的病理及免疫组织化学观察

The Observation of Brain Tissue in Encephalitis B Patients Utilizing Pathological and lmmunohistochemieal Methods

本文采用免疫荧光及PAP法对11例尸检乙脑脑组织内乙脑病毒抗原进行定位研究,并结合组织学改变进行观察。结果发现9例脑神经细胞胞浆内免疫荧光及PAP阳性(重型2例、普通型7例),其中7例普通型阳性强于2例重型。进一步证实了乙脑病毒存在于大脑神经细胞胞浆内的学说,并认为造成脑组织的病理学改变是免疫损伤所致,临床表现类型与病理改变的程度关系密切。

Brain tissue of 11 patients who died of encephalitis B were studied by immunofluorescent and PAP methods to observe pathological changes and the location of encephalitis B virus The immunofluorescent and PAP examinations were positive in nine of 11 cases-2 severe and 7 mild in type. The mild cases gave stronger reactions than the severe cases. This observation would seem to strengthen the theory that the virus of encephalitis B is located in the cytoplasm of brain cells and the pathological damage of brain tissue may be caused by an immunological reaction The clinical feature of the case with regard to signs, symptoms, and severity is related to the degree of pathologic damage to brain tissue.