同步放化疗在肺癌合并慢性阻塞性肺病患者中的疗效观察

Curative effect observation of concurrent chemoradiotherapy on patients with lung cancer and chronic obstructive pulmonary diseases(COPD)

目的探讨同步放化疗在局部晚期非小细胞肺癌(NSCLC)合并慢性阻塞性肺病(COPD)患者中的临床疗效。方法对25例局部晚期NSCLC合并COPD的患者行同步放化疗,观察其近期疗效、1年生存率、2年生存率和不良反应。结果 25例患者完全缓解1例(4%),部分缓解8例(32%),疾病稳定11例(44%),疾病进展5例(20%),临床有效率为36%,临床受益率为80%,1年生存率为36%(9/25),2年生存率为24%(6/25);出现骨髓抑制者20例(80%),放射性食管炎者12例(48%),放射性肺炎者6例(24%)。结论同步放化疗能有效治疗局部晚期NSCLC合并COPD患者,且不良反应能够耐受。

Objective To explore the clinical curative effect of concurrent chemoradiotherapy on patients with locally advanced nons mall cell lung cancer and chronic obstructive pulmonary disease. Methods Twentyfive cases with locally advanced nonsmall cell lung can cer and chronic obstructive pulmonary disease were treated with concurrent chemoradiotherapy.We observed the recent curative effect, the 1 and 2year survival rates and the adverse drug reaction.Results Among all patients, the complete remission rate was 4 % , the partial re mission rate was 32 % , the stable disease rate was 44 % , the progression rate was 20 % , the clinical effective rate was 36 % , the clinical benefit rate was 80% ,the 1 and 2year survival rates were 36% and 24% respectively.Twenty cases suffered from myelosuppression, twelve cases suffered from radiation esophagitis, six cases suffered from radiation pneumonia.Conclusion Concurrent chemoradiotherapy can treat effectively the patients with locally advanced nonsmall cell lung cancer and chronic obstructive pulmonary disease, and the adverse drug reaction can be tolerant.