病理性网络使用者反应监控功能的错误相关负波电位研究

An error-related negativity potential investigation of response monitoring function in individuals with path- ological internet use

目的通过对病理性网络使用（PIU）者执行视觉修正的Eriksen侧抑制任务的错误相关负波电位（ERN）特征检测，探讨PIU反应监控功能缺陷的发生机制。方法符合修订的《Young喇络成瘾诊断问卷》（YDQ）PIU标准的23例作为研究组，与研究组匹配性别、年龄的23例健康人作为对照组：修正的Erikson侧抑制任务包括4种靶刺激，即2种一致性刺激（〈〈〈〈〈与〉〉〉〉〉），2种不一致性刺激（〈〈〉〈〈与〉〉〈〉〉）。呈现时间250ms，被试反应时间为1100ms（包括刺激呈现时间250ms）。记录被试者执行任务时的脑电图。应用BESA5．2．0软件离线分析ERN波幅。结果PIU组错误率[（19．8±3．45）％]明显高于对照组[（13．1±2．67）％（P〈0．01）；PIU组反应时间[（440±21）ms]明显短于对照组[（495±18）ins]（P〈0．01）。重复测量的方差分析表明ERN波幅在组间、前额电极位点以及组间x前额电极位点显示主效应（组间：F=768，af=1，P=0．000；电极位点：F=615，af=2，P：0．000；组间×电极位点：F=516，df=2，P=0．000）；组间、中央电极位点以及组间×中央电极位点显示主效应（组间：F=768，df=1，P=0．000；电极位点：F=599，df=2，P=0．000；组间x中央电极位点：F=483，df=2，P=0．000）；IADERN波幅比对照组低。结论PIU存在反应监控功能功能缺陷，具有冲动控制障碍谱系的神经心理与ERP的特征，支持PIU是一种冲动控制障碍或与之相关疾病的假设。

Objective To investigate response monitoring function in individuals with pathological internet use（PIU） using the modified Eriksen flanker task by event-related potentials （ERPs）. Methods 23 individuals met Young diagnostic questionnaire（ YDQ ） criteria for PIU were enrolled as research group and 23 sexual-and age matched healthy persons enrolled as control group. EEG was recorded during participants performed the modi- fied Erikson flanker task. Reactive time （RT） and error rates were compared between two groups. BESA 5.2.0 was used to perform data analysis and the error-related negativity （ERN） amplitudes were analyzed. Results False alarm rate of PIU group was higher than that of control group. A repeated measure ANOVA re- vealed a significant group, frontal electrode sites and group frontal electrode sites main effect for ERN amplitudes （ for group ： F = 768, df= 1, P = 0. 000 ; for frontal electrode sites ： F = 615, df= 2, P = 0. 000 ; for group x frontal electrode sites ： F = 516, dr= 2, P = 0. 000） , and a significant group, central electrode sites and group central electrode sites main effect for ERN amplitudes （ for group ： F-- 768, dr= 1, P = 0. 000 ; for central electrode sites ： F = 599, df= 2, P = 0. 000 ; for group x central electrode sites ： F = 483, df= 2, P = 0.000）. ERN amplitudes of PIU group were lower than those at control group. Conclusion Individuals with PIU present response monitoring dysfunctions and share neuropsychological and ERPs characteristics of compulsive-impulsive spectrum disorder, which supports that PIU is an impulse disorder or at least related to impulse control disorder.