197例儿童异型淋巴细胞的检测及临床病因分析

Analysis of 197 Cases of Children Testing and Clinical Cause of Atypical Lymphocytes

目的:探讨儿童外周血异型淋巴细胞增高的常见病因及异型淋巴细胞的形态学特点。方法:对197例经血涂片证实的异型淋巴细胞≥0.05的儿童患者的临床资料、形态学特点进行回顾性分析。结果:197例患儿中异型淋巴细胞增高的病因包括:病毒性感染、几种病毒混合感染或病毒混合其他菌感染,形态以Ⅰ型、Ⅱ型最多见,Ⅲ型次之,个别可见两种形态的异型淋巴细胞。结论:异型淋巴细胞增高提示儿童感染病毒性疾病,及早正确的病因诊断是临床及早合理治疗的前提;同时了解到自动血液分析仪不能检出异型淋巴细胞,不能取代血细胞形态显微镜检查,实验室复检率低,检验人员掌握显微镜下异形淋巴细胞的形态特点,提高复检率是防止异型淋巴细胞漏检、误检的关键。

Objective：To investigate the children increase of heterotypic lymphocyte in peripheral blood and common causes of atypical lymphocytes morphological characteristics.Method：197 cases of blood smears demonstrated atypical lymphocytes ≥ 0.05 children patients with clinical data were retrospectively analyzed,morphological characteristics.Result：In 197 cases of children with atypical lymphocytes increased etiology,seen in viral infections and other bacterial infections of the mixed infection of several viruses or virus mixed form of type Ⅰ,Ⅱ type most common type III,followed by individual visible two forms of atypical lymphocytes.Conclusion：Atypical lymphocytes increased to prompt the children infected with viral diseases,as early as possible the correct diagnosis of the cause is a clinical as soon as possible and reasonable treatment of the premise;also learned that the automated hematology analyzer can not be detected atypical lymphocytes,and can not replace microscopic examination of blood cell morphology,laboratory complexthe inspection rate is low,inspectors hold grip shaped cells of the morphological characteristics observed under the microscope to improve the re-examination rate is to prevent the atypical lymphocytes missed and false detection the key.