2008-2011年我院口服抗组胺药利用分析

Utilization analysis of oral antihistamines in our hospital from 2008 to 2011

目的评价我院口服抗组胺药应用情况及趋势。方法对我院2008-2011年口服抗组胺药应用品种、用药金额、用药频度(DDDs)等进行统计、分析。结果我院口服抗组胺药用药金额逐年下降。第2代口服抗组胺药及其改良品种的使用量远远大于第1代,占到总额的96%以上。2008-2011年西替利嗪和左西替利嗪一直位于DDDs排序的前2位,咪唑斯汀由2008年第5位上升至2011年第3位。结论我院主要选择安全、高效、与其他药物相互作用少的第2代口服抗组胺药及其改良品种作为抗过敏治疗的主导药物,符合临床合理用药的要求。传统抗组胺药的改良剂型以及安全性更可靠的抗组胺药是研究方向。

AIM To evaluate the utilization status and development tendency of oral antihistamines in our hospi- tal. METHODS Data about clinical application of oral antihistamines in our hospital during 2008 to 2011 were analyzed statistically in terms of drug varieties, consumption sum and DDDs. RESULTS The consumption sum of oral antihis- tamines was decreased year by year. The consumption of 2nd generation oral antihistamine and improved 2nd generation oral antihistamine was far greater than the first generation, accounting for more than 96% of the total. Cetirizine and lev- ocetirizine had been at the fast two DDDs sort,and mizolastine up to three. CONCLUSION The 2nd generation oral an- tihistamine and improved 2nd generation oral antihistamine have become the dominant antiallergic drugs due to their ad- vantages of safety, high efficacy and less interaction with other drugs. The choice of antihistamines is in line with rational drug use in our hospital. The study on modified dosage form of the traditional antihistamines and the antihistamines with more reliable safety remains to be done.