脱氢表雄酮在妇产科领域的应用研究

Application of DHEA in Obstetrics and Gynecology

脱氢表雄酮(DHEA)及其硫酸盐硫酸脱氢表雄酮(DHEAS)是人体内最丰富的甾体物质,其生理作用机制尚不清楚。低水平的DHEA不仅与年龄有关,而且与糖尿病、心血管疾病、神经及免疫疾病有关。DHEA的临床应用研究已成为热点,尤其是在女性中的应用,其临床有效性在国外受到公认,但仍然缺少大量的证据支持DHEA应用的安全性。DHEA在女性中的临床研究需要大量设计科学严谨的随机对照试验。综述DHEA在妇产科的应用。

The mechanism of action of dehydroepiandrosterone （DHEA） and its sulphate DHEAS, the most abundant sex steroids in human, are not well understood. Low levels of DHEA are associated not only with the ageing process but also with diabetes mellitus,cardiovascular diseases and some neurological or immunological diseases. Clinical application and practice of DHEA have been a topic ,especially in women. Although its effectiveness has been universally acknowledged,there is scant evidence to support the safety of DHEA in clinical therapy. It is necessary to conduct the adequately powered,well-designed and randomized, and placebo-controlled trials to evaluate the clinical application of DHEA.