家兔骨生长诱导修复腭裂骨缺损的实验研究

Experimental Study of Rabbits in Repairing Bone Defect Cleft Palate by Growth Induction

目的 研究评价牛骨形成蛋白 (b BMP) -白蛋白 -成纤维细胞生长因子 (b FGF)复合材料修复腭裂骨缺损的可行性。方法 建立家兔腭骨缺损模型 ,将固化的 b BMP-白蛋白 - b FGF复合材料植入骨缺损区 ,通过其骨诱导作用 ,诱导新骨生成 ,修复骨缺损。经 X线、组织学观察和钙含量测定。结果 b BMP-白蛋白 - b FGF有很强的骨诱导作用 ,可以诱导骨形成 ,实验组与对照组 X线骨修复分数评估分别为 12分 ,0分 ,组织学检查实验组骨修复完成 ,而对照组无骨修复 ,钙含量测定也有显著性差异。。结论 b BMP-白蛋白 - b FGF复合材料可诱导修复腭骨缺损 ,有良好的临床应用前景。

Objective To study and evaluate the probability of bBMP albumin bFGF composite materials in repairing bone defect of cleft palate. [WT5,5”HZ]Methods On the basis of animal model of cleft palate bone defects in rabbits, composite materials (bBMP albumin bFGF) and single albumin were first used to repair the cleft palate bone defect respectively in rabbits, involving new bone formation and repairing bone defect by their induction effects. [WT5,5”HZ]Results The results of X ray, histological examination and calcium content check proved that bBMP albumin bFGF has strong effects of bone induction. It was able to involve induction of new bone formation in quality and quantity and repair palate bone defect in rabbits. Conclusion There is a promising prospect in use of bBMP albumin bFGF as a bone defect repairing meterial of cleft palate.