系统性红斑狼疮患者血清IL-1,SIL-2R,IL-6,IL-8的变化及临床意义

Changes in the Serum levels of IL-1,SIL-2R,IL-6 and IL-8 in Patients with Systemic Lupus Erythematosus and Its Clinic Significance

目的 通过检测系统性红斑狼疮 (SL E)患者血清白细胞介素 - 1、- 6、- 8(IL - 1、- 6、- 8)可溶性白细胞介素 - 2受体(SIL - 2 R)水平 ,探讨细胞因子和 SL E活动性的关系。方法 选择 46例活动性 SL E患者 ,并将其分成轻 ,中 ,重三组及狼疮肾(L N)和非 L N两类 ,采用 EL ISA法测定其血清 IL- 1,SIL- 2 R,IL- 6 ,IL- 8水平。结果 SL E患者血清 IL- 1,SIL- 2 R,IL- 6 ,IL- 8水平显著高于正常对照组 (P<0 .0 1) ,且和 SL E的活动度呈正相关 ,L N患者血清 SIL- 2 R,IL- 6 ,IL- 8则高于非 L N组 (P<0 .0 5 )。结论 异常增高的细胞因子可引起免疫系统网络的紊乱 ,导致免疫损伤。监测血清细胞因子可有助于了解患者狼疮活动程度 ,指导临床治疗。

Objective To evaluate the relationship between cytokines and the active systemic lupus erythematosus(SLE). Methods 46 cases with active SLE were graded in three levels (minor, medium ,serious) and grouped into two (LN, non LN). Serum levels of IL 1,SIL 2R,IL 6 and IL 8 were measured by using ELISA method. Results The serum levels of IL 1,SIL 2R,IL 6 and IL 8 in SLE patients were enhanced significantly as compared to the normal control, and the serum levels of cytokines had a positive correlation with the active SLE. Furthermore, the serum levels of SIL 2R, IL 6,IL 8 from LN patients were higher than that from non LN patients. Conclusion These results suggest that the abnormally enhanced cytokines disturb the immunity network and cause immunity damage. Thus, Measuring serum cytokines is important in clinic therapy in recognizing the degrees of SLE activity.