霉酚酸酯应用对近期肾移植后急性排斥反应的预防

Application of MMF in Prevention of Acute Renal Transplantation Rejection in the Near Period of Post operation

目的 观察霉酚酸酯 (骁悉 ,MMF)在预防肾移植术后近期 (3个月 )急性排斥反应的情况。方法 选择尸肾移植患者 112例 ,随机分成两组 :MMF(2 .0 g/ d)组和硫唑嘌呤 (AZA)组 ,两组患者均同时接受相似剂量的环孢霉素 A(Cs A)和类固醇激素治疗。结果 观察 3个月 ,急性排斥发生率 ,MMF组 6 0例 ,为 16 .6 % (10 / 6 0 ) ;AZA组 5 2例 ,为 41.5 % (2 2 / 5 2 ) ;两组差异显著 (P<0 .0 1)。 MMF组 5例发现血白细胞、血小板等不同程度下降 ,3例出现腹泻 ,在 MMF减量或停药后均恢复正常 ,未见有 MMF引起的肝、肾功能异常病例 ;AZA组有 9例出现肝功能损害。结论 MMF具有预防和减少近期急性排斥反应效果 ,且副作用轻 ,为可逆性。

Objective To observe the effect of mycophenolate mofetil (MMF) on prevention of acute renal transplantation rejection in the three months of post operation. [WT5,5”HZ]Methods 112 cases of renal transplant recipients were random divided into two groups: group MMF (2.0 g/d) and group azathioprine A (AZA). Recipients of the two groups simultaneously received similar doses of cyclosporin A(CsA) and steroids. [WT5,5”HZ]Results Within three months, the incidences of acute rejection were 16.6%(10/60) in group MMF and 41.5%(22/52) in groups AZA respectively ( P <0.01). Of the 60 recipients in groups MMF, 5 cases emerged reduction of WBC and platelet and 3 cases of diarrhea, which all recovered after taper or cessation of the usage of MMF. No cases of liver or renal dysfunction were found in group MMF while 9 cases of liver dysfunction occurred in group AZA. [WT5,5”HZ]Conclusion MMF can prevent and decrease acute renal transplantation rejection and side effects of MMF are slight and reversible.