色素上皮细胞衍生因子(PEDF)与代谢综合征(MS)关系的研究进展

Recent advances in the association of pigment epithelium-derived factor(PEDF) with metabolic syndrome(MS)

色素上皮细胞衍生因子(pigment epithelium-derived factor,PEDF)是最先在视网膜色素上皮细胞培养液中被发现的一种分泌性糖蛋白。PEDF具有神经保护、抗炎、抗血管生成、抗肿瘤等生物学功能,对糖尿病微血管并发症包括糖尿病视网膜病变和肾病有保护作用。近年来发现肥胖、代谢综合征(metabolic syndrome,MS)患者的血清PEDF水平明显升高,PEDF与MS各组分密切相关,可能是MS发生发展的生物学标志。

Pigment epithelium-derived factor（PEDF） is a secreted glycoprotein which was the first identified in the conditioned medium of cultured retinal pigment epithelial cells.Its biological functions include neuroprotection,anti-inflammation,anti-angiogenesis,anti-tumor and so on.PEDF has protective effects on diabetic vascular complications including diabetic retinopathy and nephropathy.Recently,it has been reported that plasma level of PEDF increases in subjects with obesity and metabolic syndrome（MS）.Meanwhile,PEDF is closely associated with the components of MS,and it might be a biological marker of the presence and development of MS.