急性缺血性卒中TOAST分型与外周血中内皮祖细胞含量的相关性

The research of relationship between TOAST classification and EPCs content in peripheral blood of acute ischemic stroke patients

目的观察外周血中内皮祖细胞含量变化与急性卒中TOAST(trial of org 10172 in acute stroketreatment)分型的相关性,为临床缺血性卒中的防治提供新的思路和理论基础。方法运用影像学和超声检查等方式,选择不同TOAST分型的缺血性卒中患者62例,同时选择健康体检者17例作为对照研究。运用流式细胞仪检测不同患者外周血中内皮祖细胞的含量,经统计学分析,观察不同组别患者外周血中内皮祖细胞的含量与TOAST分型是否具有相关性。结果外周血中内皮祖细胞的含量与急性缺血性卒中疾病的发生具有紧密的相关性。不同TOAST分型的内皮祖细胞数差异有统计学意义(F=5.063,P=0.001)。结论检测外周血中内皮祖细胞的含量对急性期缺血性卒中的危险分层有积极的指导作用。

Objective Observing relevance of the content of endothelial progenitor cell levels in the peripheral blood and Trial of Org10172 in Acute the Stroke Treatment to provide new ideas and theoretical basis for the prevention and treatment of clinical ischemic stroke. Methods using method such as imaging and ultrasound examination to select 62 cases of patients with different TOAST classification of ischemic stroke, at the same time to select 17 cases of healthy persons as a control study. Detecting the content of endothelial progenitor cell levels of different patients by using flow cytometry, by the SPSS statistical analysis, observing whether the content of endothelial progenitor cell levels in the peripheral blood is relevant to TOAST classification in different groups. Results the content of endothelial progenitor cell levels in the peripheral blood has a close correlation to acute ischemic stroke diseases. Difference of different TOAST classification of endothelial progenitor cell number was statistically significant （F = 5.063, P = 0.001 ）. Conclusions The detection of the content of endothelial progenitor cells in peripheral blood have an active guiding role on the risk stratification in the acute ischemic stroke.