两种曲马多超前镇痛方法对乳腺癌术后的镇痛效果

Effect of Two Tramadol Administration Methods on Postoperative Breast Cancer Pain

目的:探讨两种曲马多超前镇痛方法对乳腺癌术后的镇痛效果和安全性。方法:将90例ASA评估Ⅰ～Ⅱ级拟行乳腺癌根治术的女性患者随机分为3组,每组30例。A组:在手术切皮前10 min和缝皮前10 min给予曲马多1.5 mg/kg;B组:切皮前10min给予曲马多1.5 mg/kg;C组:手术全程不给予曲马多。观察术后0.5、1、2、4、8、12、24 h患者VAS疼痛评分和Ramsay镇静评分以及相关并发症的发生。结果:A组术后12 h以内VAS评分明显低于B组和C组,差异有统计学意义(P<0.05),B组术后2 h内VAS评分明显低于C组,差异有统计学意义(P<0.05)。结论:曲马多超前镇痛对乳腺癌根治术后有明显的镇痛作用,并且在手术开始和结束前联合给药效果更好。

Objective： To investigate the preemptive analgesic efficacy of two tramadol administration methods on postoperative breast cancer pain. Methods： Ninety ASA Ⅰ - Ⅱ female patients who underwent breast cancer surgery were randomly divided into 3 groups. Group A： Patients were administered 1.5 mg/kg tramadol 10 min before the operation and again 10 min before the end of operation, respectively. Group B： Patients were administered 1.5 mg/kg tramadol 10 min before the operation. Group C： Patients were not administered tramadol at any time. Data on pain, waking time, and side effects were recorded. Results： The Group A visual analog scale （ VAS ） values were lower than those of Groups B and C 12 h after the operation （ P 〈 0.05 ）. The Group B VAS values were lower than those of Gxoup C 2 h after the operation （ P 〈 0.05 ）. Conclusion： Tramadol preemptive analgesia has significant analgesic effects on patients who have undergone radical breast cancer operations. Combined administration 10 min before the start and the end of the operation has been proven to be the most effective.