发作期直流电漂移与难治性伴海马硬化内侧颞叶癫痫的相关性研究

Relevant research on ictal DC shift and drug-resistance mesial temporal lobe epilepsy with hippocampal sclerosis

目的探讨发作期直流电漂移(ictal DC shift)在难治性伴海马硬化的内侧颞叶癫痫(MTLE-HS)中的定位价值。方法回顾性分析18例MTLE-HS患者的临床资料,进行非侵袭性和侵袭性术前评估,对发作起始区分别使用传统频段颅内电极脑电(iEEG)技术和基于宽频脑电技术的ictal DC shift进行定位,比较两组之间的时空分布差异及其与术后病理和预后之间的关系。结果 Ictal DC shift组空间分布明显较iEEG组更为局限,时间分布晚于iEEG组。结论 Ictal DC shift可能为致痫灶的电生理标志物。

Objective To explore the localization value of ictal DC shift in mesial temporal lobe epilepsy with hippocampal sclerosis （MTLE-HS）. Methods The clinical datas of 18 patients with MTLE-HS were retrospective analyzed, and non-invasive and invasive presurgieal evaluation were carried out among all of these patients. Seizure onset zones were identified by conventional intracranial electroencephalogram （iEEG） and ictal DC shift based on windband electroencephalogram technology respectively. The variation of the time and spatial distribution were compared between the two groups with different detection methods. Results The spatial distribution of ictal DC shift was more limited than that of conventional iEEG, whereas ietal DC shift were later than iEEG. Conclusions Our findings suggest that ictal DC shift may be an eleetrophysiological marker of epileptogenie zone in MTLE-HS.