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抗反转录病毒药物血液毒性反应患者外周血CD4~＋ T和CD8~＋ T细胞计数与病毒载量相关分析 被引量：5

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摘要 获得性免疫缺陷综合症（acquired immune defi-ciency syndrome,AIDS）,即艾滋病,是人类因为感染人类免疫缺陷病毒（human immunodeficiency virus,HIV）后导致免疫缺陷,并发一系列机会性感染及肿瘤,严重者可导致死亡。在疾病的发展过程中,病毒载量与CD4＋T细胞水平已成为判定HIV感染者病程、预测临床进展以及评价抗病毒药物疗效的重要指标[1-2]。
作者 刘志斌
机构地区 河南中医学院第一附属医院艾滋病临床研究中心
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2012年第8期869-870,共2页 Chinese Journal of Cellular and Molecular Immunology
基金 国家“艾滋病和病毒肝炎等重大传染病防治”科技重大专项“十一五”计划课题(2008ZX10005-003B) 国家中医药管理局中医药重点学科建设项目(国中医药发[2009]30号) 郑州市科技创新团队建设项目(10CXTD140) 河南省教育科学“十一五”规划2010年课题(2010-JKGHAZ-0047)
关键词 血液毒性反应 CD4+T细胞计数 CD8+T细胞计数 病毒载量 Spearman检验
分类号 R512.91 [医药卫生—内科学]
  • 相关文献

参考文献8

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二级参考文献15

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共引文献29

同被引文献55

  • 1郜桂菊,张福杰,姚均,赵红心,卢联合,李鑫.HIV感染者/AIDS患者CD_4^+细胞计数与机会性感染对应关系的临床分析[J].中国艾滋病性病,2005,11(4):241-243. 被引量：87
  • 2Wang H, Nishanian P, Fahey JL. Characterization of immune sup-pression by a synthetic HIV gp41 peptide[ J]. Cell Immunol, 1995,161(2): 236 - 243.
  • 3Carr6 N,Boufassa F,Hubert JB,et al. Predictive value of viral loadand other markers for progression to clinical AIDS after CD4 + cellcount falls below 200/microL. SEROCO & HEMOCO Study Group[J]. Int J Epidemiol, 1998,27(5) : 897 - 903.
  • 4Paul ME, Shearer WT, Kozinetz CA, et al. Comparison of CD8 +Tcell subsets in HIV-infected rapid progressor children versus non-rapid progressor children [ J ]. J Allergy Clin Immunol, 2001,108(2): 258-264.
  • 5Navaneethapandian PG,Karunaianantham R, Subramanyan S, et al.CD4 + T-lymphocyte count/CD8 + T-lymphocyte count ratio: surro-gate for HIV infection in infants[ J] . J Trap Pediatr, 2012,58(5):394 -397.
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  • 10黄丹红,唐国瑶,周海文.临床医从性研究概况[J].医学综述,2009,15(8):1242-1244. 被引量：8

引证文献5

二级引证文献39

细胞与分子免疫学杂志
2012年 第8期

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