人类白细胞抗原基因多态性与药物不良反应研究进展

Research progress on human leucocyte antigen gene polymorphisms and drug adverse reactions

药物不良反应已成为危害人类健康的重要公共卫生问题。人类白细胞抗原基因(HLA)是目前已知的人类最复杂基因系统。近年来研究发现,人类白细胞抗原基因多态性与药物不良反应之间有着很强的遗传相关性,且部分研究成果在临床已得到很好地应用。本文就人类白细胞抗原基因多态性与药物不良反应之间的研究及其临床应用进行阐述。

Drug adverse reactions which are harmful to human health have become an impor- tant public health problem. Human leucocyte antigene is the most complex gene system. Re- cent years, research has demonstrated that there is a strong genetic link between HLA gene and drug adverse reactions. What＇s more, some re- search achievements have also been applied broadly in clinical practice. This review covers the progress between HLA polymorphisms and drug adverse reactions and on its clinical prac- tice.