摘要
Background There is little information of non-perianal fistulating Crohn＇s disease in the consensus published by the European Crohn＇s and Colitis Organization in 2006 and 2010. This study was designed to demonstrate the clinical characteristics of non-perianal fistulating Crohn＇s disease among homogenous Chinese population. Methods One-hundred-and-eighty-four patients were retrospectively collected. All of these patients were diagnosed of Crohn＇s disease between February 2001 and April 2011. Results The male-to-female ratio was 2.7：1. The most common symptoms at onset were abdominal pain （88.0%）, diarrhea （34.7%）, and fever （28.3%）. The most common disease location and behavior at diagnosis were small bowel （56.0%） and penetrating （51.6%）. Among 324 non-perianal fistulae, the most common types were ileocolonic anastomotic （30.9%）, terminal ileocutaneous （19.7%）, and enteroenteric anastomotic （11.4%）. One-hundred-and-thirty- eight （75.0%） patients received antibiotics, and I^-Iactam （85.5%） and metronidazole （67.4%） are most frequently used. One-hundred-and-seventy-eight （96.7%） patients suffered 514 surgical operations, and the cumulative surgical rates after 1, 3, and 5 years were 38.0%, 52.2%, and 58.7% respectively. Nine patients died during the follow-up period, and the cumulative survival rates after 1, 3, and 5 years were 97.8%, 96.7%, and 96.2% respectively. Conclusions This study displayed the clinical characteristics of non-perianal fistulating Crohn＇s disease in our center. Large population-based studies are required for further investigation in China.
Background There is little information of non-perianal fistulating Crohn＇s disease in the consensus published by the European Crohn＇s and Colitis Organization in 2006 and 2010. This study was designed to demonstrate the clinical characteristics of non-perianal fistulating Crohn＇s disease among homogenous Chinese population. Methods One-hundred-and-eighty-four patients were retrospectively collected. All of these patients were diagnosed of Crohn＇s disease between February 2001 and April 2011. Results The male-to-female ratio was 2.7：1. The most common symptoms at onset were abdominal pain （88.0%）, diarrhea （34.7%）, and fever （28.3%）. The most common disease location and behavior at diagnosis were small bowel （56.0%） and penetrating （51.6%）. Among 324 non-perianal fistulae, the most common types were ileocolonic anastomotic （30.9%）, terminal ileocutaneous （19.7%）, and enteroenteric anastomotic （11.4%）. One-hundred-and-thirty- eight （75.0%） patients received antibiotics, and I^-Iactam （85.5%） and metronidazole （67.4%） are most frequently used. One-hundred-and-seventy-eight （96.7%） patients suffered 514 surgical operations, and the cumulative surgical rates after 1, 3, and 5 years were 38.0%, 52.2%, and 58.7% respectively. Nine patients died during the follow-up period, and the cumulative survival rates after 1, 3, and 5 years were 97.8%, 96.7%, and 96.2% respectively. Conclusions This study displayed the clinical characteristics of non-perianal fistulating Crohn＇s disease in our center. Large population-based studies are required for further investigation in China.
