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胰岛素样生长因子-Ⅰ及其在头颈部肿瘤中的研究现状与展望

Present research on the status and the prospect of insulin-like growth factor-Ⅰ in head and neck cancer
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摘要 胰岛素样生长因子（insulin-like growth fac-tors,IGFs）是由Salman和Daughaday于1957年首先发现的,当时被命名为＂硫化因子＂（sulfationfactors）,随着对其生理功能的不断了解,曾经被命名为＂生长介素＂（somatomedins,SM）、NSILA（nonsuppressible insulin-like activity）,1987年研究人员分离纯化了人的2种NSILA。 Summary Insulin-like growth factor-Ⅰ （IGF-Ⅰ） is a multifunctional cell regulating factor, which plays an important role in the normal physiological activities and pathological process, This article reviewed the research status of the molecular structure of IGF-Ⅰ and its regulatory factors,the molecular biological role of IGF-Ⅰ in cell proliferation, cell motility, apoptosis, and reviewed the important role of IGF-Ⅰ in head and neck tumors, as well as put forward the prospects of IGF-Ⅰ in middle ear cholesteatoma pathogenesis.
作者 刘秀虹 蒋立新
机构地区 暨南大学附属第一医院耳鼻咽喉头颈外科 广州市番禺区南村医院五官科
出处 《临床耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2012年第15期717-720,共4页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词 胰岛素样生长因子-Ⅰ 细胞增殖 细胞迁移 凋亡 头颈部肿瘤 胆脂瘤 中耳 insulin-like growth factor-Ⅰ cell proliferation cell movement apoptosis head and neck neo-plasms cholesteatoma middle ear
分类号 R739.91 [医药卫生—肿瘤]
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参考文献29

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临床耳鼻咽喉头颈外科杂志
2012年 第15期

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