摘要
胰岛素样生长因子(insulin-like growth fac-tors,IGFs)是由Salman和Daughaday于1957年首先发现的,当时被命名为"硫化因子"(sulfationfactors),随着对其生理功能的不断了解,曾经被命名为"生长介素"(somatomedins,SM)、NSILA(nonsuppressible insulin-like activity),1987年研究人员分离纯化了人的2种NSILA。
Summary Insulin-like growth factor-Ⅰ (IGF-Ⅰ) is a multifunctional cell regulating factor, which plays an important role in the normal physiological activities and pathological process, This article reviewed the research status of the molecular structure of IGF-Ⅰ and its regulatory factors,the molecular biological role of IGF-Ⅰ in cell proliferation, cell motility, apoptosis, and reviewed the important role of IGF-Ⅰ in head and neck tumors, as well as put forward the prospects of IGF-Ⅰ in middle ear cholesteatoma pathogenesis.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2012年第15期717-720,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
胰岛素样生长因子-Ⅰ
细胞增殖
细胞迁移
凋亡
头颈部肿瘤
胆脂瘤
中耳
insulin-like growth factor-Ⅰ
cell proliferation
cell movement
apoptosis
head and neck neo-plasms
cholesteatoma
middle ear