不同途径给药参麦注射液中人参皂苷Rg1及Re在大鼠体内药代动力学研究

Pharmacokinetic study on ginsenoside Rg1 and Re in rats following intravenous and oral administration of Shenmai Injection

目的:对参麦注射液口服和静脉注射两种不同途径给药开展药代动力学研究,建立参麦注射液体内分析方法,以指导临床合理用药。方法:用高效液相色谱法测定参麦注射液不同途径给药不同时间点的血药浓度,通过药理学软件DAS3.0计算药动学参数,并计算口服生物利用度。结果:参麦注射液静脉注射给药人参皂苷Rg1、Re代谢较快,6h以后血浆中很难测到;口服给药人参皂苷Rg1、Re代谢较慢,8h达到峰浓度,生物利用度分别为7.22%、7.16%。结论:参麦注射液口服给药吸收慢,生物利用度较低,而注射给药直接进入血管,充分体现了其起效快的优势。

Carry out pharmacokinetics studies on Shen Mai injection of oral and intravenous administration two different administration routes to establish bio-analysis methods of Shen Mai injection, in order to guide rational clinical drug use. Methods ： Determine the plasma concentration that given Shen Mai injection in two different ways at different time points by HPLC method, then calculate pharmacokinetic pa- rameters with pharmacological software DAS3.0, and calculate oral bioavailability. Results ： Ginsenoside Rgl, Re in Shen Mai injection met- abolic faster by intravenous administrating, and it is difficult to measure in plasma after 6h; But it is slow by oral administration, and reach peak concentration at 8h, the oral bioavailabilitis were 7.22%, 7.16% respectively. Conclusions： Shenmai injection was absorbed slowly by oral administrating with low bioavailability, but intravenous administration manifests its superiority of fast onset by directly injected into blood vessels.