射干总黄酮抗维甲酸所致大鼠骨质疏松症的影响

The effects of the total flavonoid extracts of Rhizoma Belamcandae(射干总黄酮) on osteoporosis induced by retinoic acid in rats

目的:观察射干总黄酮对维甲酸所致大鼠骨质疏松的影响。方法:通过维甲酸造成骨质疏松模型,观察50～200 mg/kg射干总黄酮对骨质疏松大鼠骨密度、骨生物力学、骨形态计量学的影响。结果:100～200 mg/kg射干总黄酮可剂量依赖性地增加骨质疏松大鼠骨密度、改善骨生物力学指标以及骨小梁厚度,并具有性激素及促性腺激素样作用。结论:射干总黄酮提取物对维甲酸造成的骨质疏松具有改善作用。

To explore the effects of the total flavonoid extracts of Rhizoma Belamcandae on the osteoporosis induced by retinoic acid in rats. nethods：Osteoporosis model rats were induced by fed with retinoic acid （70mg/kg） and randomly separated into groups. The effects of the total flavonoid extracts of Rhizoma Belameandae （50 -200 mg/kg） on the bone mineral density, the bone construction mechanics, and histomorphometric measurement were observed. Results： Total flavonoid extracts of Rhizoma Belamcandae （100-200 mg/kg） dose-depend- ently increased bone mineral density, improved biomechanic indexs and trabecules thickness. It also improved the levels of sex hormone and gonadotropin in osteoporosis rats induced by retinoic acid. Conclusion： The total flavonoid extracts of Rhizoma Belamcandae has beneficial effects on retinoic acid-induced osteoporosis.