摘要
目的:研究滇越金线兰等剂量的总膏及其各极性部位对高脂饮食联合STZ诱导的大鼠模型血糖、血脂和肾功能的影响。方法:对滇越金线兰的总膏用不同极性的溶剂萃取,得到石油醚部位、乙酸乙酯部位、正丁醇部位和水部位。测定总膏和各极性部位对高脂饮食联合STZ诱导的模型大鼠给药后血浆的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肌酐(CRE)和尿素氮(BUN)。肾脏切片,进行病理学检查。结果:滇越金线兰的乙酸乙酯部位(4 g/kg)可以显著降低模型大鼠的血糖、改善血脂代谢,减少肌酐和尿素氮。各给药部位对糖尿病并发的早期肾损害有改善作用。结论:乙酸乙酯部位为滇越金线兰降血糖、降血脂和改善糖尿病肾病并发症的主要活性部位。
To investigate the effect of different fractions at the same dose from A. chapaensis on blood lipid and renal function in high lipid diet plus STZ induced diabetic rats. Methods: The total EtOH extract was suspended in distilled water and partitioned in sequence with petrol ether(PE), ethyl acetate(EtOAc), n-BuOH and I420, thus yielding four fractions. Blood glucose, total cholesterol (TC), triglycer- ide (TG) , low density lipoprotein cholesterol (LDL-C) , and high density lipoprotein cholesterol( HDL-C ) , creatinine (CRE) and blood usea nitrogen(BUN) in rats'plasma were assayed. Morphological examination of the kidneys were performed. Resulls: On the whole, the EtOAc fraction of A. chapaensis(4 g/kg)showed the best profile in reducing blood glucose, improving hyperlipidemic indexes and renal functions. Conclusion : The EtOAc fraction from A. chapaensis may be the active part of reducing blood lipid and improving renal function.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2012年第2期116-119,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(81001628)
关键词
滇越金线兰
降血脂
肾功能
A. chapaensis(滇越金线兰)
reducing blood lipid
renal function