Ki67在三阴性乳腺癌中的表达及与C-erbB-2的关系

The expression of Ki67 and its relationship with C-erbB-2 in triple negative breast cancer

目的:对比研究Ki67基因在三阴性及非三阴性乳腺癌中的表达,并探讨Ki67与C-erbB-2基因表达间的相关性。方法:免疫组织化学法检测320例乳腺癌标本(273例为非三阴性乳腺癌,47例为三阴性乳腺癌)中Ki67及C-erbB-2的表达。结果:较之于非三阴性乳腺癌,三阴性乳腺癌中Ki67为过表达(P<0.01)。同时Ki67与C-erbB-2的表达强度间呈正相关(P<0.01)。结论:Ki67在三阴性乳腺癌中表达升高。

Objective： To investigate the expression of Ki67 in triple negative breast cancer and the correlation be- tween the expression of Ki67 and C - erbB - 2. Methods： The expression of Ki67 and C - erbB - 2 in all 320 breast cancer samples,273 were non -triple negative and 47 were triple negative breast cancer, were analyzed by immuno- histochemistry. Then the relevance between Ki67 and C - erbB - 2 expression levels were analyzed by statistical methods. Results： The Ki67 was over expressed in triple negative breast cancer rather than non -triple negative breast cancer （P 〈 0.01 ）. And there was a positive correlation between Ki67 and C - erbB - 2 expression levels in breast cancer （P 〈 0.01 ）. Conclusion： Ki67 is overexpressed in triple negative breast cancer patients.