感毒清颗粒抗炎镇痛作用研究

Study of Ganduqing granule in the anti-inflammatory and abirritation effects

目的:考察感毒清颗粒的抗炎、镇痛作用。方法:采用二甲苯致小鼠耳肿胀法、鸡蛋清和角叉菜胶致大鼠足肿胀法、小鼠腹腔毛细血管通透性亢进法、小鼠棉球肉芽肿法和大鼠棉球肉芽肿法考察感毒清颗粒的抗炎作用;采用热板法和醋酸扭体法考察感毒清颗粒的镇痛作用。结果:抗炎作用研究表明,感毒清颗粒高、中、低剂量均对二甲苯致小鼠耳肿胀、蛋清和角叉菜胶致大鼠足肿胀、冰醋酸致小鼠毛细血管通透性亢进有显著的拮抗作用,与空白对照组比较有显著的统计学意义(P<0.05),但对大、小鼠棉球肉芽肿均无显著的抑制作用(P>0.05);热板法和醋酸扭体法研究结果表明,感毒清颗粒高、中剂量能明显提高小鼠热刺激致痛阈值,显著减少化学刺激致痛的扭体次数,与空白对照组比较有的统计学意义(P<0.05)。结论:感毒清颗粒具有良好的拮抗急性和亚急性炎症的作用,对慢性炎症无明显拮抗效应,且具有较好的镇痛作用。

Objective： The anti-inflammatory and abirritation effects that Ganduqing granule on the organism was analyzed, which providing the clinic with experimental basis. Methods ： The anti-inflammatory effects of Ganduqing granule was analyzed by using the methods as follows ： rats paw swelhng with egg white and earrageenan, rat＇s ear swelling with xylene, permeability of rat＇s abdominal capillary, tampon granuloma for mice, while its abirritation effect was analyzed by using the methods below：acetic acid to lead to mice writhing and hot plate. Results： It is find that Ganduqing granule has a significant inhibition（ P 〈0.05） on rats paw swelling with egg white and carrageenan,rat＇s ear swelling with xylene,permeability of rat＇s abdominal capillary,acetic acid to lead to mice writhing,hot plate. , while has no meaning （P 〉 0.05 ）on permeability of rat＇s abdominal capillary. Conclusion： Ganduqing granule has a significant anti-inflammatory effect on acute inflammatory and can effectively inhibit the inflammatory pains.