紫杉醇联合奥沙利铂治疗老年晚期胃癌

Paclitaxel combinde with oxaliplatin in the treatment of elderly patients with advanced gastric cancer

目的:探讨紫杉醇联合奥沙利铂(奥正南)治疗老年晚期胃癌的疗效和不良反应及对生活质量的影响。方法:65例老年晚期胃腺癌患者中,19例为初次化疗患者,15例为曾接受术后化疗,31例为未手术而接受过化疗的患者。紫杉醇80mg/m2d1,d8,静脉滴注3小时;奥沙利铂85mg/m2d2;21天为1个周期。结果:所有患者均接受2个周期的化疗后进行评效,完全缓解11例,部分缓解21例,有效率为49.2%,临床控制率为87.7%。主要不良反应为胃肠道反应,脱发,关节肌肉疼痛及骨髓抑制。结论:紫杉醇联合奥沙利铂对老年晚期胃癌疗效肯定,不良反应小,是治疗老年晚期胃癌的有效方案之一。

Objective：To explore the therapeutic efficacy of paclitexal combined with oxaliplatin in treating ad- vanced cancer of aged patients. Methods： Of 65 aged patients suffering from advanced stomach cancer, 19 patients have just received chemotherapy, 15 patients have received chemotherapy after surgery, while the other 31 patients have received chemotherapy without operation. Paclitexal 80mg/m2 d1 , ds , with 3 hours of intravenous drip, oxaliplatin 85mg/ma d2 was simultaneously applied,21 days as a circle. Results：All the patients completed chemotherapy for two circles,11 patients achived CR,21PR, with an efficiency rate of 49.2% and clinical controlling rate 87.7%. The side effects were gastrointestinal reactions, psilosis, pain in joint muscles, and arrest of bone marrow. Conclusion： Paclitexal combined with oxaliplatin has good therapeutic efficacy in treating advanced stomach cancer of aged patients with slight side effects.