CN/NFAT信号通路与骨代谢研究进展

Advances in CN/NFAT signal pathway and bone metabolism

近年来,随着对骨质疏松症研究的日益增多,与其有关的信号转导途径的研究也在深入开展。鉴于骨质疏松症的发生主要体现在由成骨细胞引起的"骨重建"与破骨细胞引起的"骨吸收"相互偶联的动态变化过程中,通过对钙调磷酸酶(calcineurin)/活化T细胞核因子(nuclear factor of activated T-cells)(CN/NFAT)信号通路的研究,以期进一步明确骨质疏松症的发病机理,为骨质疏松的治疗及预防提供新的思路和理论依据。

In recent years, with the increasing study of osteoporosis, its associated signal transduction pathways in the study also thorough development. In view of the occurrence of osteoporosis mainly embodied in the osteoblast cause by the ＂bone remodeling＂and osteoclast cause by the ＂bone absorption＂ mutual coupling dynamic changes of the process, through the study of calcineurin/nuclear factor of activated T-cells （CN/NFAT） signaling pathway, we will further clarify the pathogenesis of osteoporosis, and provide new train of thought and theory basis for the treatment and prevention of osteoporosis.