摘要
Noggin是对机体多个系统的生长发育和重塑起重要调节作用的一种糖蛋白。其对神经系统和脑发育的影响已经为人们所熟知,近年来随着研究的不断深入,noggin对骨骼系统生长发育的显著作用逐渐被人们所认识:包括调节胚胎的形态发生,抑制体外成骨细胞增值与分化,抑制体内骨形成,调节颅缝融合和关节的正常形成以及辅助治疗骨肿瘤疾病等,是调节骨生长发育的重要细胞因子。其作用机制主要是通过与BMPs相互影响,调节BMPs信号通路的过程,间接调节骨形成。
Noggin is an essential glycoprotein in the growth, development, and remodeling of many systems of human body. Its influence on the nervous system and brain development has been well known. While in recent years, the significant role of Noggin on the skeletal system is increasingly being recognized, including regulation of embryo morphogenesis, inhibition of the proliferation and differentiation of osteoblasts in vitro and bone formation in vivo, adjustment of the fusion of sutura cranii and the formation of the joint, and the adjuvant therapy of bone tumors. Noggin is a vital eytokine in the regulation of the bone formation. The possible mechanism is that Noggin interacts with BMPs, regulates BMPs signaling pathways, and regulates bone formation indirectly.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2012年第7期680-684,共5页
Chinese Journal of Osteoporosis
关键词
NOGGIN
骨形成
生长发育
机制
Noggin
Bone formation
Growth and development
Mechanism
