期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

职业接触苯并[a]芘对焦炉工人胆碱能系统及淋巴细胞凋亡率的影响 被引量：3

下载PDF
导出
摘要 苯并[a]芘具有明确的致癌性,近年来研究表明其具有神经毒性。Mendola等[1]研究发现环境污染物（包括苯并[a]芘）引起神经发育、认知和行为功能下降。焦化生产过程产生大量逸散物和煤焦油,其主要成分是多环芳烃类混合物（PAHs）,PAHs与焦炉工肺癌之间存在因果关系,在PAHs职业暴露等级评定中以苯并[a]芘当量浓度来精确描述PAHs的接触特性。因此,检测作业环境中苯并[a]芘浓度可以代表焦炉作业环境中多环芳烃类混合物的外暴露程度。
作者 郭亮 聂继胜 郑红梅 郑金平
机构地区 山西医科大学公共卫生学院卫生毒理学教研室 太原钢铁集团有限公司总医院中心实验室 山西省健康教育中心
出处 《中国药物与临床》 CAS 2012年第7期907-909,共3页 Chinese Remedies & Clinics
关键词 苯并[A]芘 焦炉工人 淋巴细胞凋亡率 胆碱能系统 职业接触 焦炉作业环境 多环芳烃类 PAHS
分类号 R131 [医药卫生—劳动卫生]
  • 相关文献

参考文献10

  • 1Mendola P,Selevan SG,Gutter S,et al. Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment Retard Dev Disabil Res Rev,2002,8(3): 188-197.
  • 2Persson E,Larsson P,Tjalve H. Cellilar activation and neuronal transport of intranasally instilled benzo[a]pyrene in the olfactory system of rats. Toxicol Lett, 2002, 133 : 211-219.
  • 3李晓华,冷曙光,郭君,关蕾,郑玉新.改良的高效液相色谱法测定尿中1-羟基芘[J].卫生研究,2003,32(6):616-617. 被引量：66
  • 4鲁祖荪,叶菲,都本业.碱性羟胺比色法测定全血乙酰胆碱[J].临床检验杂志,1992,10(2):84-85. 被引量：41
  • 5Baranski Z. Evaluation of occupational exposure to aromatic polycyclic hydrocarbons in bituminous pulp plants. Rocz Panstw Zakl Hig, 1991,42(3) :223-237.
  • 6Nicolle MM, Gonzalez J, Sugaya K, et al. Signatures of hippocam- pal oxidative stress in aged spatial learning-impaired rodents. Netlro Sei,2001,107(3) :415-431.
  • 7Katag JJ,Fang HW. Polycyclic aromatic hydrocarbons inhibit the activity of acetylcholinesterase purified from electriceel. Bioehem Biophys Res Commun, 1997,38(2) :367-369.
  • 8Akcha F, Izuel C,Venier P,et al. Enzymatic biomarker measure- ment and study of DNA adduct formation in benzo [a]pyrene contaminated mussels, mytilus galloprovincialis. Aquatic Toxicol, 2000,49 ( 4 ) : 269-287.
  • 9Cunha I,Garcia LM,Guilhermino L. Sea-urchin(Paracentrotus lividus)glutathione S-transferases and cholinesterase activities as biomarkers of environmental contamination. J Environ Monit, 2005,7(4) : 288-294.
  • 10Gladkevich A,Kauffman HF, Korf J. Lymphocytes as a neural probe: potential for studying psychiatric disorders. Prog Neu- ropsychopharmacol Biol Psychiatry, 2004,28 (3) : 559-576.

二级参考文献2

共引文献104

同被引文献24

  • 1江晓琴,倪娟,杨沛,黄蔚,罗金凤,李华凤.吗啡预处理对兔缺氧/复氧损伤肾脏组织SOD和MDA的影响[J].四川大学学报（医学版）,2010,41(5):885-887. 被引量：2
  • 2Marta S,Bozena G,Maggalena B,et al.Factors controlling benzo(a)pyrene concentration in aerosols in the urbanized coastal zone.A case study:Gdynia,Poland(Southern Baltic Sea).Environ Sci Pollut Res Int,2013;20(6):4154-4163.
  • 3Qi YB,Chen CZ,Tang Y,et al.The synergistic effect of benzo[α]pyrene and lead on learning and memory of mice.Toxicol Ind Health,2013;29(5):387-395.
  • 4Schellenberger MT,Grova N,Farinelle S,et al.Modulation of benzo[α]pyrene induced neurotoxicity in female mice actively immunized with a B[α]P-diphtheria toxoid conjugate.Toxicol Appl Pharmacol,2013;271(2):175-183.
  • 5Saunders CR,Das SK,Ramesh A,et al.Benzo(a)pyreneinduced acute neurotoxicity in the F-344rat:role of oxidative stress.J Appl Toxicol,2006;26(5):427-438.
  • 6Lin X,Ni Y,Kokot S.Glassy carbon electrodes modified with gold nanoparticles for the simultaneous determination of three food antioxidants.Anal Chim Acta,2013;2(26):54-62.
  • 7Chen C,Tang Y,Jiang X,et al.Early postnatal benzo(a)pyrene exposure in Sprague-Dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthood.Toxicol Sci,2012;125(1):248-261.
  • 8Hagan CE,McDevitt RA,Liu Y,et al.5-HT(1B)autoreceptor regulation of serotonin transporter activity in synaptosomes.Synapse,2012;66(12):1024-1034.
  • 9Qiu C,Cheng S,Xia Y,et al.Effects of subchronic benzo(a)pyrene exposure on neurotransmitter receptor gene expression in the rat hippocampus related with spatial learning and memory change.Toxicology,2011;289(2-3):83-90.
  • 10Park S,Shin H,Cho Y.Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1and 3complex.Food Chem Toxicol,2013;5(55):36-41.

引证文献3

二级引证文献4

中国药物与临床
2012年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部