血管紧张素转换酶基因多态性与慢性肾功能不全

Relationship between the polymorphism of angiotensin converting enzyme gene and chronic renal insuffciency

目的 研究血管紧张素转换酶基因多态性在慢性肾功能不全患者中的分布及意义。方法 检测 88例慢性肾功能不全患者的基因型 ,以 87例正常人为对照。结果 与对照组相比 ,基因型及等位基因频率分布 ,在失代偿期患者无差异 ,在肾衰期和尿毒症期患者存在差异 ,其中DD型频率升高 ,各为 5 7.1%和 6 1.5 %对 2 4.1% (P <0 .0 1,P <0 .0 0 1) ;II型频率在尿毒症期下降为 13 .9%对 3 1.1%(P <0 .0 5 )。结论 基因多态性与肾疾病进展有关 ,DD型是高危因素 。

Objective To study on the role of ACE genotype in the progression of chronic renal diseases. Methods ACE I/D polymorphism were detected with PCR amplification in 88 patients with chronic renal insufficiency. and 87 health subjects as controls. Results Compared with control group,genotype frequency distribution and allele frequencies were sign:ficantly different in CRF and ESRF group respectively,the frequencies for DD genotype were higer(57.1%,61.5% vs 24.1%,P<0.01,P<0.001);but the frequency for Ⅱ genotype was lower in ESRF group(13.9% vs 31.1%P<0.05). Conclusion ACE genotype are associated with the progression of renal diseases,DD genotype is a high risk factor,The detection of ACE genotype may be used as a useful marker to asses the prognosis and apply ACE inhibitors in the patients with renal diseases.