珍氯片与氯丙嗪治疗精神分裂症的比较

Chlorpromazine-pearl tablet vs chlorpromazine in treating schizophrenia

目的：比较珍氯片与氯丙嗪治疗精神分裂症的疗效和不良反应。方法：２００例精神分裂症病人分２组，珍氯片组１００例，服珍氯片８～１７片·ｄ^(-1)，氯丙嗪组１００例，服氯丙嗪２００～５００mg·d^(-1)，小剂量开始，逐步递增，均用６wk。结果：珍氯片组显效率１１％，总有效率７５％，氯丙嗪组为 １３％和８３％（Ｐ＞０．０５）。心动过速、便秘、口干等不良反应珍氯片组发生率低于氯丙嗪组（ Ｐ＜ ０． ０５）。珍氯片组血药浓度 ２， ６ wk 时为 １２２７ ｎｍｏｌ·Ｌ^(-1)± ５７１ｎｍｏｌ． Ｌ^(-1)， １４６７ nmolＬ± ５８０ ｎｍｏｌ． Ｌ^(-1)，氯丙嗪组为 １６０７ ｎｍｏｌ．Ｌ^(-1)± ６２８ ｎｍｏｌ．Ｌ^(－1)， １９８７ ｎｍｏｌ．Ｌ^(－1)± １０１０ ｎｍｏｌ·Ｌ^(-1)（均 Ｐ＜０．０１）。结论：珍氯片治疗精神分裂症疗效与氯丙嗪相似，但剂量小，不良反应少。

AIM: To compare the effects and adverse reactions of chlorpromazine-pearl tablet vs chlorprormazine in treating schizophrenia. METHODS: Two hundred patients with schizophrenia were divided into two groups: group A 100 patients took chlorpromazine-pearl tablet, 8～17 tablets· d^(-l); group B 100 patients took chlorpromazine 200～ 500 mg· d^(-1). Each group started with lower dose and continuously treated for 6 wk. RESULTS: The marked effective rate and total effective rate were respectively 11% and 75% in group A, there were 13% and 83% in group B(P >0. 05). The incidence of tachycardia, constipation, mouth drying, etc in group A was lower than that in group B (P < 0. 05). The blood concentration of chlorpromazine was respectively 1227 nmol· L^(-1)± 571 nmol ·L^(-1) and 1467 nmol· L^(-1)± 580 nlnol· L^(-1) in the 2, 6 wk in group A; 1607 nmol. L^(l) ± 628 nmol· L^（1） and 1987 nmol·L^(l) ± 1010 nmol.L^(-1) were in group B (P < 0. 01 ). CONCLUSION: Chlorpromazine- pearl tablet has similar effect to chlorpromazine, but its dose is lower and adverse reactions are less.