氟罗沙星与环丙沙星治疗细菌性感染的比较

Fleroxacin vs ciprofloxacin in treatment of bacterial infection

目的：评价氟罗沙星注射液对细菌性感染的疗效及安全性。方法：１６２例病人随机分为氟罗沙星治疗组、环丙沙星对照组各６１例和氟罗沙星开放组４０例。氟罗沙星治疗和开放组用氟罗沙星０．２～０．４ ｇ，静脉滴注，ｑｄ；环丙沙星对照组用环丙沙星，０．２～０．４ ｇ，静脉滴注，ｂｉｄ；疗程均为 ７～１４ｄ。结果：氟罗沙星注射液治疗总有效率为 ９３．１％（９３／１０１）与环丙沙星相当，治疗组有效率为９２％（５６／６１）与对照组８２％（５０／６１）相似（Ｐ＞０．０５）；但前者的细菌清除率（９４％）高于后者（８６％， Ｐ＜０． ０５）；不良反应发生率氟罗沙星（６％）也与环丙沙星（８％）相似（Ｐ＞０．０５）。结论：氟罗沙星注射液对细菌性感染有效而安全。

To evaluate the efficacy and safety of fleroxacin injection vs ciprofloxacin injection in treatment of acute bacterial infection. METHODS: One hundred and twenty-two patients with respiratory and urinary tract infections were randomly divided into 2 groups, 61 patients were treated with fleroxacin; 61 patients were treated with ciprofloxacin. Another 40 Patients treated with flexoxacin as open treated group. All were 0. 2-0. 4 g iv drip, qd (fleroxacin) or bid (ciprofloxacin) for 714 d. RESULTS: The overall clinical efficacy rates of fleroxacin was 93. 1 % (94/101 ). The randomized comparison showed that the clinical efficacy rates of fleroxacin and ciprofloxacin were similar 92% (56/ 61) vs 82% (50/61 ), P > 0. 05, but the bacterial clearance rate for fleroxacin(94% ) was higher than that for ciprofloxacin (86%, P<0. 05). The incidence of adverse reactions for fleroxacin and ciprofloxacin were 6 % and 8 %, respectively (P > 0. 05). CONCLUSION: Fleroxacin injection is an effective and Safe antihacterial for treatment of bacterial infection.