慢性束缚致大鼠慢性疲劳模型的肾上腺皮质超微结构的变化

Changes of Ultrastructure of Adrenal Gland Cortex in CFS Rat Model by Astricting Chronically

探讨慢性疲劳模型动物的肾上腺指数和肾上腺皮质的超微结构的改变及中药调节作用。用慢性束缚的方法研制慢性疲劳动物模型 ,并在模型成功的基础上处死大鼠 ,摘取肾上腺称重并在电镜下观察其皮质的超微结构。结果发现慢性束缚法造模 2周后 ,与正常组相比 ,模型组及中药复方组左侧肾上腺指数增加 ,而人参皂甙组有所降低。在此基础上观察到肾上腺皮质的超微结构的改变、功能的受损 ,是使动物HPA轴活动受影响 ,机体应激能力下降的潜在因素 ,可能是产生疲劳的原因之一。

On the basis of CFS (chronic fatigue syndrome) rat model, discuss the index and ultrastructure of adrenal gland and the modulating function of Chinese medicine. Method: After establishing rat model, excise the adrenal gland to calculate the index and observe its ultrastructure of cortex under electron microscope. Results: Compared with normal rats, the index of adrenal gland in the group with Chinese medicine increased, but the rats with ginseng saponin decreased. Observe the ultrastructure of cortex under electron microscope, the structure of normal rats and the groups with Chinese medicine and ginseng saponin were almost the same. However, a bigger change of ultrastructure occurred to rats model. Conclusion: On basis of the CFS rat model, we observed the changes of ultrastructure of cortex under electron microscope and the injuries of function. It indicated one of the causes of fatigue could be the decreasing of irritability.