大蒜素对大鼠缺氧性肺动脉高压功能形态的影响

The Inhibitory Action of Garlicin on Rat Hypoxic Pulmonary Hypertension

观察大蒜素对缺氧性腺泡内肺动脉高压是否具有阻抑效应 ,在常压缺氧条件下 ,选用 42只大鼠 ,分正常组、缺氧组、缺氧加大蒜素组 ,分别在 15d和 30d测右心室收缩压 ,并利用光镜、电镜观察肺血管病变。结果大蒜素不仅能降低肺动脉压 ,减轻缺氧对内皮细胞的损伤 ,还能阻抑腺泡内肺动脉肌化增强现象。提示大蒜素有明显阻抑缺氧性腺泡内肺动脉构型重组和预防缺氧性肺动脉压升高的作用 。

The inhibitory action of garlicin on structural remodeling of intra acinar pulmonary arteries (IAPA) under pulmonary hypertension (PHT) was studied. 42 rats were fed in hypoxic environment under normal atmospheric pressure (10%O 2 10 hours/day) and divided into control group, hypoxia group and hypoxia with garlicin group. On the 15th and 30th day of hypoxia, right ventricular systolic pressure (RVSP) was measured and pulmonary vessel changes were studied under light and electronic microscopes rspectively. Garlicin could decrease the pulmonary arteries pressure and prevent IAPA endothelial cells damage from hypoxia. Garlicin could also inhibit hypertrophic changes in tunica media, the proliferation of advantitial cellsofthe IAPA and muscularization of nonmuscular arteries. Therefore, preserving the IAPA wall cells and dilating IAPA by garlicin may play an important role in inhibiting structural remodeling of IAPA and pulmonary hypertension.