慢性胃炎胃黏膜肠上皮化生患者血清微量元素的变化与HP感染的关系

Relationship between the serum concentrations of trace elements and the infection of helicobacter pylori in the patients with metaplasia of intestinal epithelium of gastric mucosa of chronic gastritis

目的 研究慢性胃炎胃黏膜肠上皮化生患者血清中微量元素的变化及该变化与幽门螺杆菌 ( HP)感染的关系。方法 慢性胃炎肠上皮化生患者 HP阳性组 (简称 HP阳性组 ) 72例 ,HP阴性组 33例 ,用原子吸收光谱仪对其血清中微量元素进行测定。结果 慢性胃炎胃黏膜肠上皮化生患者血清铜、镍、硒均低于正常 ,但此变化在 HP阳性组和 HP阴性组之间无显著性差异 ( P >0 .0 5)。结论 慢性胃炎胃黏膜肠上皮化生病人存在着微量元素代谢紊乱 ,血清中铜、镍、硒低于正常 ,但此变化与 HP感染无相关性。

Objective To study the relationship between the serum concentrations of trace elements and the infection of helicobacter pylori (HP) in the patients with metaplasia of intestinal epithelium of gastric mucosa of chronic gastritis. Methods One hundred and five patients with metaplasia of intestinal epithelium of gastric mucosa of chronic gastritis were classified into HP positive group (n=72) and HP negative group (n=33). The serum concentrations of trace elements were measured with atomic absorption spectrophotometry. Results The levels of copper, nickel and selenium in both groups were lower than the normal levels, and there were no significant differences in the levels of copper, nickel and selenium between HP positive group and HP negative group (P>0.05). Conclusions Metabolic disorders of trace elements exist,but are not correlated with HP infections in the patients with metaplasia of intestinal epithelium of gastric mucosa of chronic gastritis.