CBX7蛋白在卵巢癌组织中的表达及意义

Expression and significance of CBX7 in ovarian tumor tissue

目的研究CBX7蛋白在正常卵巢组织和卵巢肿瘤组织中的表达及意义。方法采用免疫组织化学方法检测CBX7蛋白在90例卵巢正常组织和肿瘤组织中的表达并分析其与分期、分化、年龄、组织类型的相关性。结果 CBX7蛋白在卵巢肿瘤组织中的表达明显低于卵巢正常组织。CBX7蛋白的表达与FIGO分期以及组织分化程度相关(P<0.05)。结论 CBX7蛋白的低表达可能与卵巢癌的发生、发展有关。

Objective To investigate the expression and significance of CBX7 protein between ovarian normal tissue and tumor tissue.Methods Immunohistochemical analysis was used to measure the expression of CBX7 protein in ovarian normal tissues and tumor tissues.Results The expressions of CBX7 are reduced obviously in ovarian tumor tissue,compared with normal ovarian tissue,and the differences are statistically significant.Expressions of CBX7 are significantly different in FIGO stage and tissue differentiation（P〈0.05）.Conclusion The low expression of CBX7 protein may relate to the progress of ovarian cancer.