β-胡萝卜素的合成工艺改进

Process Improvement on the Synthesis of β-Carotene

以呋喃为原料,经水解、原位水解-Wittig反应、还原、氧化四步反应合成了β-胡萝卜素的关键中间体2,7-二甲基-2,4,6-辛三烯-1,8-二醛(5);5与季鏻盐经Wittig反应合成了β-胡萝卜素,总收率43%,其结构经1H NMR确证。

A key intermediate of β-earotene, 2,7-dimethyl-2,4,6-octatriene-1,8-dial （ 5 ）, was pre- pared by a four-step reaction of hydrolysis, in situ hydrolysis-Wittig reaction, reduction and oxidation from furan. β-Carotene in total yield of 43% was synthesized by Wittig reaction of 5 with quaternary phosphine salt. The structures were characterized by H NMR.