摘要
以磺胺吡啶和NaNO2为原料,在管式反应器中经重氮化反应合成磺胺吡啶重氮盐(2);2再与水杨酸偶合制备了柳氮磺胺吡啶,总收率87%,其结构经1H NMR,13C NMR和MS确证。
Sulfasalazine was synthesized in total yield of 87% by diazotization of sulfapyridine with NaNO2 in tubular reactor and then coupling with salicylic acid. The structure was confirmed by 1H NMR, 13C NMR and MS.
出处
《合成化学》
CAS
CSCD
北大核心
2012年第4期524-526,共3页
Chinese Journal of Synthetic Chemistry
基金
浙江省自然科学基金资助项目(Y4090346)