蛛网膜下腔阻滞对妊娠高血压综合征患者血浆一氧化氮水平的影响

Effects of subarachnoid block on plasma nitric oxide level in the patients with pregnancy induced hypertension

目的 研究蛛网膜下腔阻滞前后妊高征患者血浆一氧化氮浓度的变化。方法 选择非孕妇女 ,ASAI级 ,择期手术患者 2 0例 (非妊娠组 ) ,正常晚期妊娠妇女 2 0例 (妊娠组 ) ,重度妊高征患者 2 0例 (妊高征组 ) ,分别于蛛网膜下腔阻滞前 ,及阻滞后 10min并手术切皮前 ,取母体肘静脉血 3ml,通过测量一氧化氮代谢产物硝酸盐的方法 ,测定血浆一氧化氮的浓度。结果 蛛网膜下腔阻滞前 ,与妊娠组相比 ,非妊娠组及妊高征组的血浆一氧化氮浓度均明显降低 (P <0 0 5或 0 0 1) ;与蛛网膜下腔阻滞前相比 ,蛛网膜下腔阻滞后非妊娠组、妊娠组及妊高征组的血浆一氧化氮水平均显著升高 (P <0 0 5或 0 0 1)。结论 蛛网膜下腔阻滞可使妊高征患者血浆一氧化氮水平升高 。

Objective To observe the effects of subarachnoid block on plasma nitric oxide level of the pregnancy induced hypertension patients Methods Twenty female patients ASA class I ,scheduled for elective gynecological surgery served as non pregnancy group, 20 normal late stage gravidas as pregnancy group,and 20 severe pregnancy induced hypertension(PIH) gravidas as PIH group The intravenohs blood samples were taken immediately before subarachnoid block and 10 min following subarachnoid block(before incision),to quantify the plasma concentration of nitric oxide by measuring the metabolic production of nitric oxide:nitrite and nitrate Results Immediately before subarachnoid block,the plasma nitric oxide level decreased significantly in non pregnancy group and PIH group compared with that in pregnancy group (P<0 05 or 0 01 ) The plasma nitric oxide level increased significantly after subarachnoid block in all three groups(P<0 05 or 0 01) Conclusions Subarachnoid block can improve plasma nitric oxide level in the patient with pregnancy induced hypertension ,indicating to produce therapeutic effect on pregnancy induced hypertension