摘要
目的:探讨磁导向甲氨蝶呤缓释药物(FM-MTX)的药学参数。方法:采用分光光谱法、高效液相色谱法、原子吸收光谱法检测磁导向甲氨蝶呤缓释药物的含量及组成,并对FM-MTX的比重、沸点、粒径和稳定性进行检测。结果:HPLC法检测FM-MTX中MTX药物含量为260mg/L。Fe3O4平均含量为66.29mg/L。FM-MTX粒度分布均匀,粒径为0.4~1.0μm,占88.61%。FM-MTX药物含量稳定,放置6个月,含量未见明显变化。
Objective: To determine pharmaceutical parameters of magnetic targeted ferromagnetic albumin methotrexate conjugates (FM MTX) as a slow release antitumor drug.Methods:The pharmaceutical parameters of FM MTX were determined with ultraviolet spectrophotometry,high performance liquid chromatography (HPLC) and atomic absorption spectrophotometry.Results:The mean content of methotrexate in FM MTX was 260 mg/L and Fe 3O 4 66.29 mg/L. The diameter of FM MTX particles was 0.8~1.0 μm.The measurements of the preparation were stable within 6 months.Conclusion:FM MTX is stable in both contents and particle size.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2000年第1期65-67,共3页
Journal of Practical Stomatology
基金
国家自然科学基金!资助项目390 70 871
国家新药基金!资助项目 93- (62 ) - N- 4 2
关键词
甲氨蝶呤
磁微球
靶向给药系统
抗癌药
Methotrexate
Magnetic microspheres
Targeting drug delivery system