胰肾联合移植二例报告

Simultaneous kidney pancreas transplantation:Report of 2 cases

目的 为了改善Ⅰ型糖尿病末期肾衰患者的治疗效果。方法 于 1 998年 6月和 1 999年 5月先后施行了 2例胰肾联合移植术 ,免疫抑制方案采用激素、CsA、骁悉 (MMF)及抗胸腺淋巴细胞球蛋白 (ATG)。 结果 联合移植术后胰肾功能恢复正常 ,病人均于术后 2 4小时内停用胰岛素 ,一周内血肌酐及尿素氮降为正常。 1例已有功能存活 1 3个月 ,另 1例早期恢复良好 ,术后 3周发生急性排斥 ,7周时死于复数菌败血症。结论 胰肾联合移植是治疗Ⅰ型糖尿病终末期肾衰的有效手段。

Objective To improve therapeutic effects of end stage of type I diabetic patients with advanced renal failure. Methods From Jun.of 1998 to May of 1999,two patients in end stage of type I diabetes mellitus received simultaneous kidney pancreas transplantation(SKPT).The immunosuppressive protocol consisted of prednisolone,CsA,MMF and ATG. Results The functions of pancreas and kidney grafts returned to normal within 24 hours and 7 days respectively.One patient with functional grafts remained alive for thirteen months after the operation.Another recovered well on early stage,but the kidney graft was acutely rejected in three weeks and the patient died of septicemia at the 7th week postoperatively. Conclusion SKPT is an effective therapeutic measure for end stage type I diabetes mellitus.