黄芪注射液治疗出血性中风急性期随机对照试验的系统评价

A Systematic Review of Astragalus Injection for Clinical Effect of Acute Hemorrhagic Stroke

目的系统评价黄芪注射液治疗出血性中风急性期的疗效及安全性。方法检索黄芪注射液治疗出血性中风急性期随机对照试验研究,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta分析、漏斗图分析、敏感性分析等统计相关数据。结果 3项研究符合选择标准,均为低质量研究。Meta分析结果显示,总有效率比较的相对危险度RR(99%的可信区间)为1.32(1.07,1.63),NNT(99%CI)为4.55(2.70,16.67)。结论 Meta分析结果显示黄芪注射液具有改善出血性中风急性期患者神经功能缺损状况的作用,且安全性较高。

Objective： To evaluate efficacy and safety of astragalus injection for acute hemorrhagic stroke.Methods： The eligible studies of randomized controlled trails（RCTs） of astragalus injection for acute hemorrhagic stroke were identified.The methodological quality of inclusive trails was assessed by Jadad scale.Heterogeneity test,Meta-analysis,funnel plot analysis and sensitivity analysis were used to analyse data.Results： 3 RCTs which were low quality research were included.Meta-analysis indicated that relative risk of overall effective rate was 1.32[99%CI（1.07,1.63）],NNT（99%CI） was 4.55（2.70,16.67）.Conclusion： This systematic review shows that astragalus injection is effective for acute hemorrhagic stroke.