动态监测急性心肌梗死患者心肌损伤标志物的价值

The value of myocardial injury markers dynamic monitored on patients with acute myocardial infarction

目的探讨急性心肌梗死(AMI)患者心肌损伤标志物动态监测价值。方法选取我院2009年7月至2010年8月收治的60例AMI患者及同期健康体检者40名为研究对象,测定2组的蛋白肽类标志物C反应蛋白(CRP)、肌钙蛋白(IcTnI)及酶学标志物肌酸激酶同工酶(CK-MB)、天冬氨酸转氨酶(AST)的含量。并测定AMI患者2～4 h内CRP、cTnI、CK-MB、AST的阳性率。结果 AMI的CRP、CK、CK-MB、AST的水平均高于对照组,差异有统计学意义(P<0.05)。AMI患者在2～4 h内蛋白肽类标志物CRP、cTnI高于酶学标志物CK-MB、AST,差异有统计学意义(P<0.05)。结论 CRP、cTnI、CK-MB、AST都是检测AMI患者心肌损伤的良好指标,但蛋白肽类标志物CRP、cTnI的价值要高于酶学标志物CK-MB、AST,在临床诊断时可根据实际情况联合应用。

Objective To explore the value of myocardial injury markers dynamic monitored on patients with acute myocardial infarction （AMI）. Methods Sixty patients with AMI were selected from July 2009 to August 2010 in our hospital,and the healthy check-up 40 cases as the research object were selected in the same period. The protein peptide marke~ of C-reactive protein （CRP）, troponin I （cTnI） and the enzymology markers of creatine kiuase isozymes （CK- MB）, aspartate amino shift enzyme （AST） from 2 groups were determined. The positive of CRP, eTnI, CK-MB, AST in 2-4 h of patients with AMI were determined. Results The level of CRP, cTnI, CK-MB and AST of patients with AMI were significantly higher than those in the control group （P〈0.05）. The lever of protein peptide markers CRP, eTnI were significantly higher than enzymology markers CK-MB, AST in 2-4 h on patients with AMI （P〈0.05）. Conclusion The CRP, cTnI, CK-MB, AST are good index in testing the status of myocardial injury on patients with AMI, but the value of protein peptide markers CRP, cTnI is better than that of enzymology markers CK-MB, AST, and the index should be combined application in clinical diagnosis according to actual situation.