64排动态CT脑灌注成像在脑梗死缺血半暗带中的临床应用

The practicality of cerebral ischemic penumbra applying dynamic 64-slice CT perfusion imaging

目的应用64排动态CT脑灌注成像技术探讨脑梗死缺血半暗带情况。方法观察测量43例存在缺血半暗带脑梗死患者的梗死核心区、缺血半暗带区及其镜像对侧各灌注参数值。结果 43例缺血半暗带区表现为平均通过时间(MTT)、达峰时间(TTP)均延长,脑血流量(CBF)下降,而脑血容量(CBV)表现为轻度升高、正常或轻度降低。缺血半暗带区与梗死核心区比较,CBV、CBF、MTT及TTP值差异均有统计学意义(P<0.05)。缺血半暗带与健侧对应区比较,CBF、MTT、TTP值差异有统计学意义,CBV差异无统计学意义。结论应用64排动态CT脑灌注成像,对脑梗死患者可明确病变部位、范围以及有无缺血半暗带的存在。

Objective To explore the practicality of cerebral ischemic penumbra applying dynamic 64-slice CT perfusion imaging. Methods The perfusion parameters were measured at infarct core area, ischemic penumbra, and mirror area of theirs in 43 cases with ischemic penumbra. Results In ischemic penumbra of the 43 cases, mean transit time （MrFF） and time to peak （TFP） delayed, cerebral blood flow （CBF） decreased, but cerebral blood volume （CBV） slightly decreased, normal or slightly increased. There were statistically significant difference on CBV, CBF, MTY and TI＇P between ischemic penumbra and infarct core area of the 43 cases. Between the 43 cases of ischemic penumbra and the control apteral corresponding region, there were statistically significant difference on CBF, MTF and TIP, but CBV was no significant difference. Conclusion Application of dynamic 64-slice CT perfusion imaging can make sure the area of the cerebral lesions and whether existence of ischemic penumbra.