藿香正气液对湿困脾胃证模型小鼠的作用研究

The function of Huoxiang Zhengqi liquid against Shikun Piwei syndrome model mouse

目的:建立湿困脾胃证模型小鼠,观察藿香正气液对模型小鼠的胃肠道功能的作用影响。方法:30只KM种小鼠随机分为湿困脾胃证模型组、治疗组,正常组,每组10只。模型组每日灌服熟地混合液(0.5ml/只)并置于人工气候箱中饲养8h;治疗组除按模型组方法饲养外每日还需灌服藿香正气液(0.5ml/只);空白对照组置于常温环境下饲养并每日灌服蒸馏水(1ml/只)。建模6d后通过观察小鼠的一般体征、胃排空和肠推进能力、胃肠病理组织病变等方面来了解小鼠胃肠功能的改变。结果:与正常组相比,模型组小鼠胃排空和肠推进能力下降,胃肠组织炎症水肿,粘液分泌增多,经藿香正气液治疗后基本恢复到正常水平。结论:藿香正气液有改善湿困脾胃证小鼠胃肠功能失调的作用,这可能是其防治湿困脾胃证的作用机制之一。

Objective： To establish Shikun Piwei syndrome model mice, to observe the effect of Huoxiangzhengqi liquid against Shikun Piwei syndrome model mouse. Methods： 30 KM mice were randomly divided into Shikun Piwei syndrome group, the treatment group and normal group, 10 cases in each group. Rehmannia mixture of model group fed Rehmannia mixture liquid daily （0.5ml/only） and placed in the artificial climate chamber kept for 8h; treatment group in addition to the model group method for keeping the daily needed gavage Huoxiangzhengqi liquid （0.5ml/only）; blank control group were kept in temperature environment, feeding with distilled water （lml/only）. Modeling after 6days, by observing the general signs, gastric emptying and intestinal propulsion capability, gastrointestinal pathology tissue lesions of the mouse to understand the changes of gastrointestinal function in the mouse. Results： Comparing with the normal group, gastric emptying and intestinal propulsion of model mice in decline, gastrointestinal tissue inflammation edema, increased mucus secretion returned to normal levels after by Huoxiang Zhengqi fluid treatment. Conclusion： Huoxiang Zhengqi liquid can improve the Shikun Piwei syndrome mice and gastrointestinal dysfunction, which may be one of the mechanisms to prevent wet storm.