低钾型周期性麻痹的血清肌酶改变及其临床意义

CHANGE OF SERUM CREATINE PHOSPHKINASE FOR HYPOKALEMIC PERIODIC PARALYSIS PATIENTS AND ITS CLINICAL SIGNIFICANCE

目的探讨低钾型周期性麻痹(HOPP)患者血清肌酶的改变及其临床意义。方法对2006年1月—2011年6月本院收治的78例HOPP患者的临床和实验室检查资料进行回顾性分析,并观察其血清肌酶改变与血钾降低程度的关系。结果 78例HOPP患者肌酶各项指标均有不同程度的升高,其中以肌酸激酶(CK)升高最显著,肌酸激酶和天门冬氨酸转氨酶(AST)升高的患者分别65例(83.3%)和51例(65.4%)。肌酶升高的时间稍迟于血钾的降低,恢复亦迟于血钾的恢复。结论血清肌酶各项指标普遍升高且呈一定规律性,是反映低钾患者病情的重要指标,是原发性低钾型周期性麻痹的临床特征的重要组成部份。

Objective To discuss the change and clinical significance of serum creatine phosphkinase for hypokalemic periodic paralysis patients.Methods The clinical data and laboratory documents of 78 patients with hypokalemic periodic paralysis（HOPP） who were in hospital from Jan,2006 to Jun,2011 were retrospectively studied and summarized,as well as the relationship between the change of serum creatine phosphokinase and the decrease of blood kal was also studied.Results There was an overall rise with various degrees in all creatine indexes of HOPP patients,among which the elevation of CK was the most common and prominent.The patients with CK rise and AST rise were 65 cases（83.3%） and 51 cases（65.4%） respectively.The more serious of hypokalemic the higher elevation of CK was,and the time of increased creatase was slightly slower than that of decreased blood kal as well as the recovery of creatase was also slower than that of blood kal.Conclusions All indexes of the serum creatinase elevates with certain rules,it is the important index showing symptoms and the most critical part of clinical characteristics of idiopathic hypokalemic periodic paralysis.