摘要
目的:探讨妊娠糖尿病孕妇糖化血红蛋白(HbA1c)、甲状腺激素水平的变化及临床意义。方法:选择妊娠糖尿病孕妇127例为病例,随机选取同期正常妊娠妇女179例,测定三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、总甲状腺素(T4)、游离甲状腺素(FT4)、促甲状腺素(TSH)及空腹血糖(FBG)水平,并与HbA1c进行相关性分析。结果:与正常妊娠妇女相比,妊娠糖尿病孕妇的T3、FT3、T4、FT4水平明显下降,差异均有统计学意义(P<0.01);HbA1c与FBG明显上升(P<0.01);HbA1c与FBG呈正相关(r=0.44,P<0.01),与FT3呈负相关(r=-0.29,P<0.05)。结论:HbA1c是监测妊娠糖尿病病情的良好指标,妊娠糖尿病孕妇存在甲状腺激素水平低下的现象。
Objective: To investigate the variations of glycosylated hemoglobin ( HbA1 c ) and thyroid hormones and their clinical significance in gestational diabetes mellitus patients. Method: A number of 127 gestational diabetes mellitus patients were selected as case group, 179 normal pregnant women in the same period were randomly selected as control group. Triiodothyronine (T3) , thyroid hormones free triiodothyro-nine ( FT3 ), total thyroxine ( T4 ), free thyroxine ( FT4 )., thyroid stimulating hormone ( TSH ) and fasting blood sugar (FBG) were detected and correlation analysis were conducted between HbAlc and the above in-dex. Result: The T3 ,FT3 ,T4 ,FT4 levels were significantly lower ( P〈0. 05 ) in gestational diabetes mellitus patients, while HbAlc and FBG were significantly higher ( P〈0.01 ) than those in normal pregnant women. HbAlc had a positive correlation with FBG ( r=0.44, P〈0.01 ) , and a negative correlation with FT3 ( r=-0.29,P〈0.05 ). Conclusion: HbAlc is a good index for monitoring the gestational diabetes condition, low levels of thyroid hormone are existed in diabetes mellitus patients.
出处
《河北医学》
CAS
2012年第8期1060-1063,共4页
Hebei Medicine
关键词
妊娠糖尿病
糖化血红蛋白
甲状腺激素
Gestational diabetes mellitus
Glycosylated hemoglobin
Thyroid hormones