T—SPOT与PPD对结核病患者的临床诊断价值的探讨

Clinical Diagnostic Value of T-SPOT and PPD in Patients with Tuberculosis

目的探讨结核菌素试验（PPD）和T—SPOT对结核病患者的临床诊断价值。方法对我院2011年1月至11月收治的222例结核病患者进行PPD试验和外周血T-SPOT检测，并分析其结果。结果222例结核病患者中，PPD阳性者139例，PPD的阳性率为62．6％（139／222），T-SPOT阳性者192例，T-SPOT的阳性率为86．5％（192／222），两种阳性率经过统计学处理差异具有显著性。在139例PPD阳性患者中，PPD（＋）57例，PPD（＋＋）75例，PPD（＋＋＋）7例。而这三组中，对应的T—SPOT阳性的病例分别为：52、75和7例，T—SPOT和PPD的符合率为96．40％（134／139）。在PPD（＋＋）以上的患者中，两种检测技术的符合率达100％（82／82）。结论T-SPOT作为一种新的诊断技术，在结核病的临床诊断中具有较好的应用价值。

objective To explore the clinical diagnostic value of tuberculin test （PPD） and interferon-gamma release assay （T-SPOT） in patients with tuberculosis. Methods 222 patients with tuberculosis hospitalized in our hospital from Jan. 2011 to Nov. 2011 were detected with PPD and T-SPOT. The data were collected and analyzed. Results Of 222 cases, 139 were positive in PPD and 192 were positive in T-SPOT. The positive rate was 62.8% and 86.5%, respectively. The difference was significant statistically. There were 57 cases with PPD （＋）, 75 cases with PPD （＋＋） and 7 cases with PPD （＋＋＋） among 139 cases with PPD positive. T-SPOT were positive in 52 cases with PPD （＋）, 75 cases with PPD （＋＋） and 7 cases with PPD （＋＋＋）. The accordant rate was 96.4% among PPD positive patients and 100% among patients with PPD （＋＋） and PPD （＋＋＋）. Conclusions T-SPOT is very useful tool to diagnose tuberculosis as a new technique in clinical practice.