摘要
抗抑郁药物在双相情感障碍中的应用备受关注。抗抑郁药物治疗双相抑郁急性期疗效较为肯定,但有转躁等问题;长期治疗的预防效果尚有待进一步研究。本文从循证医学角度,综述抗抑郁药物在双相情感障碍(主要是双相抑郁)急性期和维持期治疗中的疗效以及转躁情况,阐述双相情感障碍治疗中抗抑郁药物合理使用的重要性和必要性。
Antidepressants in the treatment of bipolar affective disorder remain a clinical hot topic. It is effective to use antidepressants in the acute treatment of bipolar depression. However, the patients switch to manic episode easily sometimes. The long-term preventive efficacy has not been demonstrated. Based on medical point of view, this review discusses the efficacy of antidepressants in the acute and maintenance treatment of bipolar affective disorder including the risk of switching to manic episode. It also describes the importance and necessity in rational use of antidepressants.
出处
《世界临床药物》
CAS
2012年第7期388-390,430,共4页
World Clinical Drug
关键词
双相情感障碍
双相抑郁
抗抑郁药物
转躁
bipolar affective disorder
bipolar depression
antidepressant
switch to manic episode
